Full list of publications:

Bartus, K, Galiano J, James ND, Hernandez-Miranda LR, Dawes JM, Fricker FR, Garratt AN, McMahon SB, Ramer MS, Birchmeier C, Bennett DL, Bradbury EJ (2016) Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury. Brain 139: 1394-1416 OPEN ACCESS

Didangelos A, Puglia M, Iberl, M , Sanchez-Bellot C, Roschitzki B, Bradbury EJ (2016) High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury. Sci Reports 6:21607 131-135. OPEN ACCESS

James ND, Shea J, Muir EM, Verhaagen J, Schneider BL, Bradbury EJ (2015) Chondroitinase gene therapy improves upper limb function following cervical contusion injury. Exp Neurol 271: 131-135. PubMed

Kwon BK, Streijger F, Hill CE, Anderson AJ, Bacon M, Beattie MS, Blesch A, Bradbury EJ, Brown A, Bresnahan JC, Case CC, Colburn RW, David S, Fawcett JW, Ferguson AR, Fischer I, Floyd CL, Gensel JC, Houle JD, Jakeman LB, Jeffery ND, Jones LA, Kleitman N, Kocsis J, Lu P, Magnuson DS, Marsala M, Moore SW, Mothe AJ, Oudega M, Plant GW, Rabchevsky AS, Schwab JM, Silver J, Steward O, Xu XM, Guest JD, Tetzlaff W. (2015) Large animal and primate models of spinal cord injury for the testing of novel therapies. Exp Neurol 269: 154-168. PubMed

Bradbury EJ, Ramer MS, Ramer LM. (2015) Sulfonylureas--a novel treatment to reduce tissue damage after acute spinal cord injury?--Authors' reply. Lancet Neurol 14: 352-353. PubMed

Ramer LM, Ramer MS, Bradbury EJ (2014) Restoring function after spinal cord injury: towards clinical translation of experimental strategies. Lancet Neurol 13: 1241-1256. PubMed

Didangelos A, Iberl M, Vinsland E, Bartus K, Bradbury EJ (2014) Regulation of IL10 by chondroitinase ABC promotes a distinct immune response following spinal cord injury. J Neurosci 34:16424-32. PubMed

Bartus K, James ND, Didangelos A, Bosch KD, Verhaagen J, Yanez-Munoz RJ, Rogers JH, Schneider BL, Muir EM, Bradbury EJ (2014) Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury. J Neurosci 34: 4822-36. PubMed

Burnside ER, Bradbury EJ (2014) Manipulating the extracellular matrix and its role in brain and spinal cord plasticity and repair. Neuropathol Appl Neurobiol 40:26-59. PubMed

Starkey ML, Bartus K, Barritt AW, Bradbury EJ (2012) Chondroitinase ABC promotes compensatory sprouting of the intact corticospinal tract and recovery of forelimb function following unilateral pyramidotomy in adult mice. Eur J Neurosci 36:3665-78. PubMed

Oudega M, Bradbury EJ, Ramer MS (2012) Combination Therapy for Spinal Cord Injury. Handbook of Clinical Neurology 109:617-36. Volume Editors Joost Verhaagen and John W. McDonald III; Series Editors Michael J. Aminoff, Francois Boller and Dick Swaab. PubMed

Bosch KD, Bradbury EJ, Verhaagen J, Fawcett JW, McMahon SB (2012) Chondroitinase ABC promotes plasticity of spinal reflexes following peripheral nerve injury. Exp Neurol 238:64-78. PubMed

Bradbury EJ (2012) Rewiring the spinal cord: introduction to the special issue on plasticity after spinal cord injury. Exp Neurol 235:1-4. PubMed

Bartus K, James ND, Bosch KD, Bradbury EJ (2012) Chondroitin sulphate proteoglycans: key modulators of spinal cord and brain plasticity. Exp Neurol 235:5-17 [Epub 2011 Aug]. PubMed

James ND, Bartus K, Grist J, Bennett DL, McMahon SB, Bradbury EJ (2011) Conduction failure following spinal cord injury: functional and anatomical changes from acute to chronic stages. J Neurosci 31: 18543-55. PubMed

Carter LM, McMahon SB, Bradbury EJ (2011) Delayed treatment with chondroitinase ABC reverses chronic atrophy of rubrospinal neurons following spinal cord injury. Exp Neurol 228: 149-56. PubMed

Bradbury EJ, Carter LM (2011) Manipulating the glial scar: Chondroitinase ABC as a therapy for spinal cord injury. Brain Res Bull 84: 306-16. [Epub 2010 Jul]. PubMed

Agudo M, Yip P, Davies M, Bradbury EJ, Doherty P, McMahon S, Maden M, Corcoran JP (2010) A retinoic acid receptor beta agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord. Neurobiol Dis 37:147-55. Epub 2009 Oct 2. PubMed

Webber DJ, Yip P, Bradbury EJ, Minger SL, McMahon SB (2009) Neural progenitors promote axon growth in vitro and ex vivo but not following injury. J Stem Cells 4:1-16. PubMed

Starkey ML, Davies M, Yip PK, Carter LM, Wong DJ, McMahon SB, Bradbury EJ (2009) Expression of the regeneration-associated protein SPRR1A in primary sensory neurons and spinal cord of the adult mouse following peripheral and central injury. J Comp Neurol 513:51-68. PubMed

Marchand F, Tsantoulas C, Singh D, Grist J, Clark AK, Bradbury EJ, McMahon SB (2009) Effects of Etanercept and Minocycline in a rat model of spinal cord injury. Eur J Pain 13:673-81. PubMed

Carter LM, Starkey ML, Akrimi SF, Davies M, McMahon SB, Bradbury EJ (2008) The yellow fluorescent protein (YFP-H) mouse reveals neuroprotection as a novel mechanism underlying chondroitinase ABC-mediated repair after spinal cord injury. J Neurosci 28:14107-14120. PubMed

Cafferty WB, Bradbury EJ, Lidierth M, Jones M, Duffy PJ, Pezet S, McMahon SB (2008) Chondroitinase ABC-mediated plasticity of spinal sensory function. J Neurosci 28:11998-12009. PubMed

Garcia-Alias G, Lin R, Akrimi SF, Story D, Bradbury EJ, Fawcett JW (2008) Therapeutic time window for the application of chondroitinase ABC after spinal cord injury. Exp Neurol 210:331-338. PubMed

Webber DJ, Bradbury EJ, McMahon SB, Minger SL (2007) Transplanted neural progenitor cells survive and differentiate but achieve limited functional recovery in the lesioned adult rat spinal cord. Regen Med 2:929-945. PubMed

Eickholt BJ, Ahmed AI, Davies M, Papakonstanti EA, Pearce W, Starkey ML, Bilancio A, Need AC, Smith AJ, Hall SM, Hamers FP, Giese KP, Bradbury EJ, Vanhaesebroeck B* (2007) Control of Axonal Growth and Regeneration of Sensory Neurons by the p110delta PI 3-Kinase. PLoS ONE 2:e869 PubMed

Clark AK, Gentry C, Bradbury EJ, McMahon SB, Malcangio M (2007) Role of spinal microglia in rat models of peripheral nerve injury and inflammation. Eur J Pain 11:223-230. PubMed

Barritt AW, Davies M, Marchand F, Hartley R, Grist J, Yip P, McMahon SB, Bradbury EJ (2006) Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury. J Neurosci 26:10856-10867 PubMed

Yip PK, Wong LF, Pattinson D, Battaglia A, Grist J, Bradbury EJ, Maden M, McMahon SB, Mazarakis ND (2006) Lentiviral vector expressing retinoic acid receptor beta2 promotes recovery of function after corticospinal tract injury in the adult rat spinal cord. Hum Mol Genet 15:3107-3118. PubMed

Bradbury EJ, McMahon SB (2006) Spinal cord repair strategies: why do they work? Nat Rev Neurosci 7:644-653. PubMed

Moreno-Flores MT, Bradbury EJ, Martin-Bermejo MJ, Agudo M, Lim F, Pastrana E, Avila J, az-Nido J, McMahon SB, Wandosell F (2006) A clonal cell line from immortalized olfactory ensheathing glia promotes functional recovery in the injured spinal cord. Mol Ther 13:598-608. PubMed

Starkey ML, Barritt AW, Yip PK, Davies M, Hamers FP, McMahon SB, Bradbury EJ (2005) Assessing behavioural function following a pyramidotomy lesion of the corticospinal tract in adult mice. Exp Neurol 195:524-539. PubMed

Agudo M, Robinson M, Cafferty W, Bradbury EJ, Kilkenny C, Hunt SP, McMahon SB (2005) Regulation of neuropilin 1 by spinal cord injury in adult rats. Mol Cell Neurosci 28:475-484. PubMed

Cronin JN, Bradbury EJ, Lidierth M (2004) Laminar distribution of GABAA- and glycine-receptor mediated tonic inhibition in the dorsal horn of the rat lumbar spinal cord: effects of picrotoxin and strychnine on expression of Fos-like immunoreactivity. Pain 112:156-163 PubMed

Averill S, Michael GJ, Shortland PJ, Leavesley RC, King VR, Bradbury EJ, McMahon SB, Priestley JV (2004) NGF and GDNF ameliorate the increase in ATF3 expression which occurs in dorsal root ganglion cells in response to peripheral nerve injury. Eur J Neurosci 19:1437-1445. PubMed

Ramer MS, Bradbury EJ, Michael GJ, Lever IJ, McMahon SB (2003) Glial cell line-derived neurotrophic factor increases calcitonin gene-related peptide immunoreactivity in sensory and motoneurons in vivo. Eur J Neurosci 18:2713-2721. PubMed

Bradbury EJ, Moon LD, Popat RJ, King VR, Bennett GS, Patel PN, Fawcett JW, McMahon SB (2002) Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature 416:636-640. PubMed

Malcangio M, Getting SJ, Grist J, Cunningham JR, Bradbury EJ, Charbel IP, Lever IJ, Pezet S, Perretti M (2002) A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones. FASEB J 16:730-732. PubMed

Charbel IP, Lever IJ, Michael GJ, Bradbury EJ, Malcangio M (2001) Intrathecally delivered glial cell line-derived neurotrophic factor produces electrically evoked release of somatostatin in the dorsal horn of the spinal cord. J Neurochem 78:221-229. PubMed

Lever IJ, Bradbury EJ, Cunningham JR, Adelson DW, Jones MG, McMahon SB, Marvizon JC, Malcangio M (2001) Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of afferent fiber stimulation. J Neurosci 21:4469-4477. PubMed

Ramer MS, Bradbury EJ, McMahon SB (2001) Nerve growth factor induces P2X(3) expression in sensory neurons. J Neurochem 77:864-875.PubMed

Bradbury EJ, McMahon SB, Ramer MS (2000) Keeping in touch: sensory neurone regeneration in the CNS. Trends Pharmacol Sci 21:389-394. PubMed

King VR, Bradbury EJ, McMahon SB, Priestley JV (2000) Changes in truncated trkB and p75 receptor expression in the rat spinal cord following spinal cord hemisection and spinal cord hemisection plus neurotrophin treatment. Exp Neurol 165:327-341. PubMed

Ramer MS, Harper GP, Bradbury EJ (2000) Progress in spinal cord research - a refined strategy for the International Spinal Research Trust. Spinal Cord 38:449-472 PubMed

Farquhar-Smith WP, Egertova M, Bradbury EJ, McMahon SB, Rice AS, Elphick MR (2000) Cannabinoid CB(1) receptor expression in rat spinal cord. Mol Cell Neurosci 15:510-521. PubMed

Bradbury EJ, Khemani S, Von R, King, Priestley JV, McMahon SB (1999) NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord. Eur J Neurosci 11:3873-3883. PubMed

Thompson SW, Bennett DL, Kerr BJ, Bradbury EJ, McMahon SB (1999) Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord. Proc Natl Acad Sci USA 96, 7714-7718 PubMed

Kerr BJ, Bradbury EJ, Bennett DL, Trivedi PM, Dassan P, French J, Shelton DB, McMahon SB, Thompson SW (1999) Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord. J Neurosci 19:5138-5148. PubMed

Bradbury EJ, Burnstock G, McMahon SB (1998) The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor. Mol Cell Neurosci 12:256-268. PubMed

Bradbury EJ, King VR, Simmons LJ, Priestley JV, McMahon SB (1998) NT-3, but not BDNF, prevents atrophy and death of axotomized spinal cord projection neurons. Eur J Neurosci 10:3058-68. PubMed

Abdulla FA, Bradbury EJ, Calaminici MR, Lippiello PM, Wonnacott S, Gray JA, Sinden JD (1996) Relationship between up-regulation of nicotine binding sites in rat brain and delayed cognitive enhancement observed after chronic or acute nicotinic receptor stimulation. Psychopharmacol 124:323-31. PubMed

Bradbury EJ, Kershaw TR, Marchbanks RM, Sinden JD (1995) Astrocyte transplants alleviate lesion induced memory deficits independently of cholinergic recovery. Neuroscience 65:955-972. PubMed